WHAT IS DELSTRIGO?
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DELSTRIGO is a complete, one-pill prescription HIV medicine used to treat human immunodeficiency virus-1 (HIV-1) infection in adults who have not taken HIV-1 medicines before. HIV is the virus that causes AIDS (Acquired Immune Deficiency Syndrome).

 

Speak Up About All Medications You're Taking Before Taking DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate)
Speak Up About All Medications You're Taking Before Taking DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate)

TAKING DELSTRIGO

BEFORE YOU START

Before treatment with DELSTRIGO, tell your doctor about all of your medical conditions, including if you: have hepatitis B, kidney problems, bone problems, or a history of bone fractures; are pregnant or plan to become pregnant; or are breastfeeding or plan to breastfeed. It is not known if DELSTRIGO can harm your unborn baby. Do not breastfeed if you take DELSTRIGO. Women with HIV should not breastfeed because their babies could be infected with HIV through their breast milk.

Before Treatment With DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate), Tell Your Doctor About All of Your Medical Conditions
DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) Is One Pill Taken Once a Day, at About the Same Time Every Day, With or Without Food

HOW TO TAKE IT

DELSTRIGO is one pill taken once a day, at about the same time every day, with or without food.

DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) Is One Pill DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) Is One Pill
ONE PILL
DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) Should Be Taken Once a Day DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) Should Be Taken Once a Day
ONCE A DAY
DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) Should Be Taken With or Without Food DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) Should Be Taken With or Without Food
WITH OR WITHOUT FOOD

DELSTRIGO is usually taken by itself (without other HIV medicines)

Tell your doctor if you have taken rifabutin in the past 4 weeks

If you take the medicine rifabutin during treatment with DELSTRIGO, your doctor will also prescribe an additional dose of doravirine for you because you may not have enough doravirine in your blood. Carefully follow your doctor’s instructions about when to take doravirine and how much to take. This is usually 1 tablet of doravirine about 12 hours after your last dose of DELSTRIGO

Take DELSTRIGO every day exactly as your doctor tells you to take it

Do not change your dose or stop taking DELSTRIGO without talking to your doctor. Stay under a healthcare provider's care when taking DELSTRIGO

Before Treatment With DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate), Tell Your Doctor About All of Your Medical Conditions

DO NOT MISS OR SKIP DOSES

What to do if you forget
If you miss a dose of DELSTRIGO, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at your regular time. Do not take two doses of DELSTRIGO at the same time.

What to do if you run out
When your DELSTRIGO supply starts to run low, get more from your healthcare provider or pharmacy. This is very important because the amount of virus in your blood may increase if the medicine is stopped for even a short time. The virus may develop resistance to DELSTRIGO and become harder to treat.

DELSTRIGO AND OTHER MEDICATIONS

WHAT TO KNOW. WHAT TO EXPECT.

Getting and staying undetectable is extremely important, but it's also important to consider whether your HIV-1 treatment can be used with other medicines.

DELSTRIGO may be taken with a wide range of non-HIV medications used to treat pain, heartburn, and cholesterol. It can also be taken with birth control.

DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) Can Be Taken With Statins for Cholesterol

STATINS

(atorvastatin)

CHOLESTEROL

DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) Can Be Taken With Proton Pump Inhibitors for Heartburn

PROTON PUMP INHIBITORS

(pantoprazole)

HEARTBURN

DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) Can Be Taken With Oral Contraceptives for Birth Control

ORAL CONTRACEPTIVES

(ethinyl estradiol and levonorgestrel)

BIRTH CONTROL

DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) Can Be Taken With Methadone for Pain

METHADONE

PAIN

DELSTRIGO should be avoided if you are using or have recently used nonsteroidal anti-inflammatory drugs (NSAIDs)

Some medicines interact with DELSTRIGO. Before starting DELSTRIGO, tell your doctor if you have ever had an allergic reaction to lamivudine, or if you are taking any of the following medicines: carbamazepine, oxcarbazepine, phenobarbital, phenytoin, enzalutamide, rifampin, rifapentine, mitotane, or St. John’s wort.

 
Your Doctor Can Tell You if it Is Safe to Take DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) With Other Medications
DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) May Be Taken With a Wide Range of Medications
 

WHAT TO KEEP IN MIND

Your doctor can tell you if it is safe to take DELSTRIGO with other medicines. You can ask them or your pharmacist for a list of medicines that interact with DELSTRIGO. Do not start taking a new medicine without telling your doctor.

When talking to your doctor about treatment options, be sure to tell them about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) May Be Taken With a Wide Range of Medications Your Doctor Can Tell You if it Is Safe to Take DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) With Other Medications
DELSTRIGO™ (doravirine/lamivudine/tenofovir disoproxil fumarate) Is One Pill Taken Once a Day, at About the Same Time Every Day, With or Without Food

 

 
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For United States, its territories, and Puerto Rico only. US-DOR-00181 09/19

Worsening of hepatitis B virus infection (HBV). If you have both HIV-1 and HBV and stop taking DELSTRIGO, your HBV may suddenly get worse. Do not stop taking DELSTRIGO without first talking to your healthcare provider, as they will need to monitor your health. Your doctor should test you for HBV infection before you start treatment with DELSTRIGO.